Bimix: Papaverine HCI + Phentolamine Mesylate - Intravernosal Injection

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Erectile Dysfunction...

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BiMix is administered as a penile self-injection, typically considered to be a powerful class of anti-erectile dysfunction agents. While the components of BiMix (Papaverine, Phentolamine) are, on their own, indicated for a vast number of different conditions, the practice of bringing them together in concert to treat erectile dysfunction has become commonplace in sexual medicine and is now considered the go-to treatment if a patient is not responsive to conventional PDE5 inhibitors. BiMix is used in the treatment of erectile dysfunction in males. BiMix contains two drugs from complimentary classes designed to act synergistically, mixed into a sterile injection. They are:

Papaverine: Blocks the breakdown of cAMP and cGMP (cyclic Guanosine Mono-Phosphate), leading to a decrease in intracellular calcium and the relaxation of smooth muscle that may result in and has been reported to increase duration of erection.

Phentolamine: A non·selective Alpha Blocker adjunct therapy that inhibits smooth muscle contraction and has a direct effect on smooth muscle activity. Phentolamine has been reported to provide a synergistic effect when combined with PGEI and Phentolamine.

Additonal Information

• Porst. H (1996). The rationale for Prostaglandln E1 In erectile failuire: A survey of worldwide experience. Joumal of urology 155, 802-815

2196 Main St. Suite A, Dunedin FL 34698