Clindamycin Phosphate: Clindamycin is an effective antibiotic in the treatment of infections caused by certain gram-positive and gram-negative anaerobic microorganisms.
Benzoyl Peroxide: Benzoyl peroxide is a topical acne product. Benzoyl peroxide exhibits antibacterial activity. It also has drying actions, sebostatic effects, and causes mild skin desquamation. Benzoyl peroxide improves both inflammatory and non-inflammatory acne lesions. Benzoyl peroxide is effective as monotherapy in mild cases of acne and is used as an adjuvant in moderate to severe cases of acne. A study 1 in the United Kingdom showed that an OTC 5% benzoyl peroxide topical formulation (Panoxyl Aquagel) was as effective as topical benzoyl peroxide/erythromycin combination and the oral tetracyclines minocycline and oxytetracycline for treatment of mild to moderate acne. Topical benzoyl peroxide and benzoyl peroxide/erythromycin combinations were not associated with propionibacterial antibiotic resistance which occurs with the tetracyclines. Benzoyl peroxide has also been used in the off-label treatment of decubitus ulcers. Benzoyl peroxide is available as prescription and non-prescription products and is available in combination with erythromycin, hydrocortisone, and sulfur (see separate monographs for each of the combination products). The FDA has revised labeling requirements for all non-prescription (over-the-counter) topical acne products, including benzoyl peroxide, to ensure consistency with the standardized 'Drug Facts' formatting. Benzoyl peroxide is a generally recognized as safe and effective (GRASE) active ingredient in over-the-counter topical acne drug products.
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