Metronidazole + Niacinamide Compounded - Topical Cream

Price: $39.95

Skin Care...


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2196 Main St. Suite A
Dunedin, FL 34698

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Description

Metronidazole: Metronidazole is classified therapeutically as an antiprotozoal and antibacterial agent

Niacinamide: The physiologic role of niacinamide is as a precursor to important cofactors: nicotinamide adenine dinucleotide (NAD) and its phosphate derivative (NADP). These cofactors and their reduced forms (NADH and NADPH) serve as redox co-enzymes in many enzymatic reactions, and the reduced forms are anti-oxidants. Thus, it is possible that niacinamide has these multiple effects on skin indirectly as a result of its role as a co-enzyme precursor, although defining specifically how these dinucleotides fit mechanistically into all the observed skin effects is not clearly defined. Since NADH and NADPH are anti-oxidants and their levels can be increased with niacinamide, a possible effect of topical niacinamide is inhibition of oxidative processes such as protein oxidation (glycation).

Glycation (Maillard reaction) is a spontaneous oxidative reaction between protein and sugar, resulting in cross-linked proteins (Amedori products) that are yellowish-brown in color and are fluorescent. These products can accumulate in matrix components such as collagen that have long biological half-lives. There is thus potential for glycation to have a significant role in the normal aging-induced changes in skin appearance (e.g. yellowing of skin, also more technically described as skin sallowness) and for niacinamide to inhibit the appearance change.
 

Additonal Information

2196 Main St. Suite A, Dunedin FL 34698